HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → N-[6-Chloro-2-(1-piperazinyl)-5-quinolinyl]-4-(trifluoromethyl)-cyclohexaneacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | N-(2,6-Dichloro-5-quinolinyl)-4-(trifluoromethyl)-cyclohexaneacetamide | HCID 86609736 | — |
| Product | N-[6-Chloro-2-(1-piperazinyl)-5-quinolinyl]-4-(trifluoromethyl)-cyclohexaneacetamide | HCID 11408427 | 24.5% |
Reaction Steps
Prepared according to the method of example 2 using N-(2,6-dichloro-5-quinolinyl)-4 (trifluoromethyl)-cyclohexaneacetamide (Example 8 (c)) (200 mg) and piperazine (420 mg). Purification (SiO2, dichloromethane:methanol 95:5 as eluant) afforded the title compound as a solid (55 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-3de383c4ff9449d9a032a3b010fcdbc4 |
| Source note | uspto-grants-2008_08 |