Piperazine → N-[6-Chloro-2-(1-piperazinyl)-5-quinolinyl]-4-(trifluoromethyl)-cyclohexaneacetamide

HRID 2217804Notes

Reaction equation

HRID 2217804 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:26])[C:8]=2[NH:12][C:13](=[O:25])[CH2:14][CH:15]2[CH2:20][CH2:19][CH:18]([C:21]([F:24])([F:23])[F:22])[CH2:17][CH2:16]2)[N:3]=1.[NH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[Cl:26][C:7]1[C:8]([NH:12][C:13](=[O:25])[CH2:14][CH:15]2[CH2:20][CH2:19][CH:18]([C:21]([F:24])([F:23])[F:22])[CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86609736N-(2,6-Dichloro-5-quinolinyl)-4-(trifluoromethyl)-cyclohexaneacetamide

Product 1

HCID 11408427N-[6-Chloro-2-(1-piperazinyl)-5-quinolinyl]-4-(trifluoromethyl)-cyclohexaneacetamideYield 24.5%

Procedure

Prepared according to the method of example 2 using N-(2,6-dichloro-5-quinolinyl)-4 (trifluoromethyl)-cyclohexaneacetamide (Example 8 (c)) (200 mg) and piperazine (420 mg). Purification (SiO2, dichloromethane:methanol 95:5 as eluant) afforded the title compound as a solid (55 mg).

Workup

  1. customPrepared
  2. customPurification (SiO2, dichloromethane:methanol 95:5 as eluant)

Sources & evidence

ORD record
ord-3de383c4ff9449d9a032a3b010fcdbc4
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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