tert-Butyl ethyl(prop-2-en-1-yl)carbamate → HCID 86609737, compound

HRID 2217809Notes

Reaction equation

HRID 2217809 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[CH2:23]([N:25]([CH2:33][CH:34]=[CH2:35])[C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])[CH3:24]>>[CH:15]1([CH2:14][C:13]([NH:12][C:8]2[C:7]([CH3:22])=[CH:6][CH:5]=[C:4]3[C:9]=2[CH:10]=[CH:11][C:2]([CH2:35][CH2:34][CH2:33][N:25]([CH2:23][CH3:24])[C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[N:3]3)=[O:21])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 71365398tert-Butyl ethyl(prop-2-en-1-yl)carbamateHCID 86013006HCID 86013006, compound

Product 1

HCID 86609737HCID 86609737, compoundYield 44%

Procedure

Prepared according to the method of example 1(b), using N-(2-chloro-6-methyl-5-quinolinyl)-cyclohexaneacetamide (Example 15 (a)) (400 mg) and ethyl(2-propenyl)-carbamic acid, 1,1-dimethylethyl ester (Example 15 (b)) (277 mg). Purification (SiO2, ethyl acetate:isohexane 20:80 as eluant) gave the sub-title compound (260 mg).

Workup

  1. customPrepared
  2. customPurification (SiO2, ethyl acetate:isohexane 20:80 as eluant)

Sources & evidence

ORD record
ord-76664c7494f440daa958a8a906ebfa14
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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