tert-Butyl ethyl(prop-2-en-1-yl)carbamate → HCID 11442565, compound

HRID 2217810Notes

Reaction equation

HRID 2217810 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.CC(OC(=O)[N:29]([CH2:33][CH3:34])[CH2:30][CH:31]=[CH2:32])(C)C>>[ClH:1].[ClH:1].[Cl:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([CH2:32][CH2:31][CH2:30][NH:29][CH2:33][CH3:34])[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 71365398tert-Butyl ethyl(prop-2-en-1-yl)carbamateHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 11442565HCID 11442565, compoundYield 57.1%

Procedure

Prepared according to the method of example 15, using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1(a)) (500 mg) and ethyl(2-propenyl)carbamic acid 1,1-dimethylethyl ester (330 mg). Recrystallisation (methanol/ethyl acetate) afforded the title compound as a solid (195 mg).

Workup

  1. customPrepared
  2. customRecrystallisation (methanol/ethyl acetate)

Sources & evidence

ORD record
ord-846ea24a190a4217b6503abb8a35453e
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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