5-Aminoquinoline → 4-Methyl-N-5-quinolinyl-cyclohexaneacetamide

HRID 2217813Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2217813
[N:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([NH2:11])[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH3:12][CH:13]1[CH2:18][CH2:17][CH:16]([CH2:19][C:20](O)=[O:21])[CH2:15][CH2:14]1>>[CH3:12][CH:13]1[CH2:18][CH2:17][CH:16]([CH2:19][C:20]([NH:11][C:6]2[CH:7]=[CH:8][CH:9]=[C:10]3[C:5]=2[CH:4]=[CH:3][CH:2]=[N:1]3)=[O:21])[CH2:15][CH2:14]1

Komponenten

3

Edukt 2

HCID 119115-AminoquinolineHCID 36169452-(4-Methylcyclohexyl)acetic acid

Produkt 1

HCID 114148714-Methyl-N-5-quinolinyl-cyclohexaneacetamideAusbeute 17,2 %

Versuchsvorschrift

Prepared according to the method of example 18, using 5-quinolinamine (250 mg) and 4-methyl-cyclohexaneacetic acid (270 mg). Purification (HPLC, Symmetry—0.1% aqueous trifluoroacetic acid/acetonitrile) followed by recrystallisation from methanol/ethyl acetate gave the title compound as a colourless solid (84 mg).

Aufarbeitung

  1. customPrepared
  2. customPurification (HPLC, Symmetry—0.1% aqueous trifluoroacetic acid/acetonitrile)
  3. customfollowed by recrystallisation from methanol/ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-2827e7d8b9054818ab65e65ad4b6b197
Quelldatensatz
uspto-grants-2008_08
Patentnummer
US07408065B2

Notizen zur Reaktion

Wird geladen…