化工社化工社 化学情報印刷レポート · 研究参考用
5-Aminoquinoline → 4-Methyl-N-5-quinolinyl-cyclohexaneacetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Aminoquinoline | HCID 11911 | — |
| 反応物 | 2-(4-Methylcyclohexyl)acetic acid | HCID 3616945 | — |
| 生成物 | 4-Methyl-N-5-quinolinyl-cyclohexaneacetamide | HCID 11414871 | 17.2% |
反応手順
Prepared according to the method of example 18, using 5-quinolinamine (250 mg) and 4-methyl-cyclohexaneacetic acid (270 mg). Purification (HPLC, Symmetry—0.1% aqueous trifluoroacetic acid/acetonitrile) followed by recrystallisation from methanol/ethyl acetate gave the title compound as a colourless solid (84 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07408065B2 |
| 出典データセット | uspto-grants-2008_08 |
| ORD ID | ord-2827e7d8b9054818ab65e65ad4b6b197 |
| 出典メモ | uspto-grants-2008_08 |