HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide → N-[6-Chloro-2-[3-[(3-hydroxypropyl)amino]propyl]-5-quinolinyl]-cyclohexaneacetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide | HCID 86012996 | — |
| Reactant | Tert-butyl allyl(3-(tert-butyldimethylsilyloxy)propyl)carbamate | HCID 86595927 | — |
| Product | N-[6-Chloro-2-[3-[(3-hydroxypropyl)amino]propyl]-5-quinolinyl]-cyclohexaneacetamide | HCID 11750436 | 13% |
Reaction Steps
Prepared according to the method of example 1(b)/(c), using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1(a)) (130 mg) and [3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]-2-propenyl-carbamic acid, 1,1-dimethylethyl ester (example 22(a)) (152 mg). Purification (SiO2, methanol:dichloromethane 1:9 as eluant) gave the title compound as a colourless solid (21 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-f6d8cd73edef48fb90d12684422ffc10 |
| Source note | uspto-grants-2008_08 |