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2,6-Dichloroquinolin-5-amine → 1-Cyclohexyl-N-(2,6-dichloro-5-quinolinyl)-cyclopropanecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,6-Dichloroquinolin-5-amine | HCID 24820374 | — |
| 反応物 | 1-Cyclohexylcyclopropane-1-carboxylic acid | HCID 53745023 | — |
| 生成物 | 1-Cyclohexyl-N-(2,6-dichloro-5-quinolinyl)-cyclopropanecarboxamide | HCID 86013011 | 50.8% |
反応手順
Prepared according to the method of example 1(a), using 2,6-dichloro-5-quinolinamine (prepared as described in Example 1(d)) (0.3 g) and 1-cyclohexyl cyclopropanecarboxylic acid (Example 26(a)) (0.28 g) at 100° C. for 15 hours. Purification by chromatography (SiO2, dichloromethane as eluant) afforded the sub-title compound (0.26 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07408065B2 |
| 出典データセット | uspto-grants-2008_08 |
| ORD ID | ord-aaf481ec2c2b46d1b699aee8cfedb2d3 |
| 出典メモ | uspto-grants-2008_08 |