Piperazine → HCID 11485412, compound

HRID 2217836Notes

Reaction equation

HRID 2217836 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[NH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 4837PiperazineHCID 86013006HCID 86013006, compound

Product 1

HCID 11485412HCID 11485412, compoundYield 44.1%

Procedure

Prepared according to the method of example 2, using N-(2-Chloro-6-methyl-5-quinolinyl)-cyclohexaneacetamide (Example 15(a)) (0.2 g) and piperazine (0.163 g). The reaction was cooled to room temperature, the resulting solid collected by filtration and recrystallised from methanol to afford the title compound (0.102 g).

Workup

  1. customPrepared
  2. filtrationthe resulting solid collected by filtration
  3. customrecrystallised from methanol

Sources & evidence

ORD record
ord-f3f38d16a0474fe08a5ced6ae4f0484d
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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