反应详情

温度

120 °C

N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1(a)) (0.2 g), (3S)-3-piperidinamine (0.089 g) and triethylamine (0.25 mL) were placed into a 10 mL microwave vial followed by the addition of acetonitrile (5 mL). The vial was sealed and heated at 120° C. in a single mode microwave for 30 minutes, and a further 60 minutes at 150° C. The product crystallised from the reaction on cooling and was subsequently filtered and washed with acetonitrile (10 mL). Purification (SiO2, 7M ammonia in methanol:methanol:dichloromethane 1:4:95) gave the title compound (0.055 g).

1. customThe vial was sealed
2. customa further 60 minutes
3. customat 150° C
4. customThe product crystallised from the reaction
5. temperatureon cooling
6. filtrationwas subsequently filtered
7. washwashed with acetonitrile (10 mL)
8. customPurification (SiO2, 7M ammonia in methanol:methanol:dichloromethane 1:4:95)