(3S)-(-)-3-Aminopyrrolidine → HCID 11153408, compound

HRID 2217859Notes

Reaction equation

HRID 2217859 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH2:15][CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[N:3]=1.[NH:23]1[CH2:27][CH2:26][C@H:25]([NH2:28])[CH2:24]1>>[NH2:28][C@H:25]1[CH2:26][CH2:27][N:23]([C:2]2[CH:11]=[CH:10][C:9]3[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=3[NH:12][C:13](=[O:21])[CH2:14][CH2:15][CH:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)[N:3]=2)[CH2:24]1

Participants

3

Reactant 2

HCID 1519351(3S)-(-)-3-AminopyrrolidineHCID 86013046HCID 86013046, compound

Product 1

HCID 11153408HCID 11153408, compoundYield 69.7%

Procedure

Prepared according to the method of example 30, using N-(2,6-dichloro-5-quinolinyl)-cyclopentanepropanamide (Example 62(a)) (500 mg) and (3S)-3-pyrrolidinamine (390 mg). Purification (SiO2, methanol:dichloromethane:ammonium hydroxide solution 7:93:1 as eluant) gave the title compound as a solid (400 mg).

Workup

  1. customPrepared
  2. customPurification (SiO2, methanol:dichloromethane:ammonium hydroxide solution 7:93:1 as eluant)

Sources & evidence

ORD record
ord-297a749fb5f846569427bc74a0762eb1
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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