Ethyl 4-piperidinecarboxylate → HCID 68810206, compound

HRID 2217866Notes

Reaction equation

HRID 2217866 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:22])[C:8]=2[NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[N:3]=1.[NH:23]1[CH2:28][CH2:27][CH:26]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:25][CH2:24]1>>[Cl:22][C:7]1[C:8]([NH:12][C:13](=[O:21])[CH2:14][CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:23]1[CH2:28][CH2:27][CH:26]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:25][CH2:24]1)[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 86012996N-(2,6-Dichloro-5-quinolinyl)-cyclohexaneacetamide

Product 1

HCID 68810206HCID 68810206, compoundYield 73.6%

Procedure

Prepared according to the method of example 30, using N-(2,6-dichloro-5-quinolinyl)-cyclohexaneacetamide (Example 1(a)) (200 mg) and 4-piperidinecarboxylic acid, ethyl ester (280 mg). Purification (SiO2, ethyl acetate:isohexane 25:75 as eluant) gave the sub-title compound as an oil (200 mg).

Workup

  1. customPrepared
  2. customPurification (SiO2, ethyl acetate:isohexane 25:75 as eluant)

Sources & evidence

ORD record
ord-c41547d84ed94959984bf1a20b5d3838
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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