反应详情

温度

50 °C

Potassium hydroxide (2 mL, 50% solution in water) was added to a stirred solution of N-[6-chloro-2-(3-cyanopropyl)-5-quinolinyl]-cyclohexaneacetamide (Example 67(a)) (190 mg) in methanol (2 mL). The reaction mixture was heated to 50° C. for 6 hours then allowed to cool. The mixture was acidified with aqueous 2M hydrochloric acid until a precipitate formed which was collected by filtration. Purification by HPLC (Symmetry—0.1% aqueous ammonium acetate/acetonitrile) afforded the title compound as a solid (45 mg).

1. temperatureto cool
2. customformed which
3. filtrationwas collected by filtration
4. customPurification by HPLC (Symmetry—0.1% aqueous ammonium acetate/acetonitrile)