Ethyl 4-piperidinecarboxylate → HCID 68809358, compound

HRID 2217875Notes

Reaction equation

HRID 2217875 reaction equation
Cl[C:2]1[CH:11]=[CH:10][C:9]2[C:8]([C:12]([NH:14][CH2:15][CH:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:13])=[C:7]([Cl:22])[CH:6]=[CH:5][C:4]=2[N:3]=1.[NH:23]1[CH2:28][CH2:27][CH:26]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:25][CH2:24]1>>[Cl:22][C:7]1[C:8]([C:12]([NH:14][CH2:15][CH:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:13])=[C:9]2[C:4](=[CH:5][CH:6]=1)[N:3]=[C:2]([N:23]1[CH2:28][CH2:27][CH:26]([C:29]([O:31][CH2:32][CH3:33])=[O:30])[CH2:25][CH2:24]1)[CH:11]=[CH:10]2

Participants

3

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 860130222,6-dichloro-N-(cyclohexylmethyl)-5-quinolinecarboxamide

Product 1

HCID 68809358HCID 68809358, compoundYield 73.6%

Procedure

Prepared according to the method of example 30, using 2,6-dichloro-N-(cyclohexylmethyl)-5-quinolinecarboxamide (Example 43(a)) (200 mg) and 4-piperidinecarboxylic acid, ethyl ester (470 mg) to afford the sub-titled compound as a solid (200 mg).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8be77f65917640efb10a28132820f5e6
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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