HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyclohexylethylamine → 1-[6-Chloro-5-[[(2-cyclohexylethyl)amino]carbonyl]-2-quinolinyl]-4-piperidinecarboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyclohexylethylamine | HCID 20509 | — |
| Reactant | 6-Chloro-2-[4-(ethoxycarbonyl)-1-piperidinyl]-5-quinolinecarboxylic acid | HCID 68808948 | — |
| Product | 1-[6-Chloro-5-[[(2-cyclohexylethyl)amino]carbonyl]-2-quinolinyl]-4-piperidinecarboxylic acid ethyl ester | HCID 68808940 | 70.8% |
Reaction Steps
Prepared according to the method of example 4(a), using 6-chloro-2-[4-(ethoxycarbonyl)-1-piperidinyl]-5-quinolinecarboxylic acid (example 76(c)) (217 mg) and cyclohexaneethanamine (277 mg). Purification (SiO2, methanol:dichloromethane 1:99 as eluant) gave the title compound as a solid (200 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07408065B2 |
| Source dataset | uspto-grants-2008_08 |
| ORD ID | ord-086e6816f30d47779ad9397533ee4e27 |
| Source note | uspto-grants-2008_08 |