反应详情

温度

80 °C

N-[6-Chloro-2-[(3R)-3-[(methylsulfonyl)oxy]-1-piperidinyl]-5-quinolinyl]-cyclohexaneacetamide (Example 80(a)) (0.2 g) and 8M methylamine in ethanol (5 ml) were placed into a 10 ml microwave vial and heated at 80° C. for 60 minutes within a single mode microwave. The reaction was pre-absorbed onto silica and purified (SiO2, 7M ammonia in methanol:methanol:dichloromethane 1:3:96 as eluant). The resulting product was recrystallised from acetonitrile to afford the title compound (0.007 g).

1. customThe reaction was pre-absorbed onto silica
2. custompurified (SiO2, 7M ammonia in methanol:methanol:dichloromethane 1:3:96 as eluant)
3. customThe resulting product was recrystallised from acetonitrile