Cyclohexanepropanoic acid → N-(2,6-Dichloro-5-quinolinyl)-cyclohexanepropanamide

HRID 2217894Notes

Reaction equation

HRID 2217894 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:8]([NH2:12])=[C:7]([Cl:13])[CH:6]=[CH:5][C:4]=2[N:3]=1.[CH:14]1([CH2:20][CH2:21][C:22](O)=[O:23])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[Cl:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:13])[C:8]=2[NH:12][C:22](=[O:23])[CH2:21][CH2:20][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:3]=1

Participants

3

Reactant 2

HCID 69702Cyclohexanepropanoic acidHCID 248203742,6-Dichloroquinolin-5-amine

Product 1

HCID 86012849N-(2,6-Dichloro-5-quinolinyl)-cyclohexanepropanamide

Procedure

Prepared according to the method of example 62(a), using 2,6-dichloroquinolin-5-amine (example 1(d)) (0.5 g) and cyclohexanepropionic acid (1.2 mL). The resulting precipitate was filtered and washed with acetone. The precipitate was further washed with water and then ether to give the sub-title compound as a solid (0.248 g)

Workup

  1. customPrepared
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with acetone
  4. washThe precipitate was further washed with water

Sources & evidence

ORD record
ord-a3b9ff56b53c43c195568aaeca3bbc90
Source dataset
uspto-grants-2008_08
Patent number
US07408065B2

Reaction notes

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