反应详情

Prepared according to the method of example 90(b), using N-(2,6-dichloro-5-quinolinyl)-cyclohexanepropanamide (Example 90(a)) (0.16 g), N,N′-dimethylpropanediamine (0.3 mL) and triethylamine (0.1 mL). Purification (SiO2, methanol:dichloromethane:triethylamine 5:95:0.5 followed by HPLC, Symmetry—0.1% aqueous trifluoroacetic acid:acetonitrile) gave the title compound as a solid (70 mg).

1. customPrepared
2. customPurification (SiO2, methanol:dichloromethane:triethylamine 5:95:0.5 followed by HPLC, Symmetry—0.1% aqueous trifluoroacetic acid:acetonitrile)