反应详情

温度

60 °C

Phosphorous oxychloride (2 mL) was added to 6-chloro-5-[[(2-cyclohexylethyl)amino]carbonyl]-1-hydroxy-quinolinium Example 94(c)) (0.089 g) and the mixture heated at 60° C. for 2 hours. The reaction mixture was concentrated under reduced pressure and added to water. The aqueous was extracted with ethyl acetate and the combined organics dried filtered and evaporated give the sub titled compound as a solid (0.079 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionadded to water
3. extractionThe aqueous was extracted with ethyl acetate
4. customthe combined organics dried
5. filtrationfiltered
6. customevaporated