Piconol → HCID 10215905, compound

HRID 2217982Notes

Reaction equation

HRID 2217982 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][OH:8].[Cl:9][C:10]1[S:14][C:13]([S:15]([NH:18][C:19]2[C:24](Cl)=[N:23][CH:22]=[CH:21][N:20]=2)(=[O:17])=[O:16])=[CH:12][CH:11]=1>>[Cl:9][C:10]1[S:14][C:13]([S:15]([NH:18][C:19]2[C:24]([O:8][CH2:7][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)=[N:23][CH:22]=[CH:21][N:20]=2)(=[O:16])=[O:17])=[CH:12][CH:11]=1

Participants

3

Reactant 2

HCID 11474PiconolHCID 10215019HCID 10215019, compound

Product 1

HCID 10215905HCID 10215905, compound

Conditions

Temperature
70 °C

Procedure

Prepared by the method of Example 20b using pyridine-2-methanol and 5-chloro-N-(3-chloro-2-pyrazinyl)-2-thiophenesulphonamide with reaction mixture heated at 70° C. for 4 h.

Workup

  1. customPrepared by the method of Example 20b
  2. customwith reaction mixture

Sources & evidence

ORD record
ord-06f71d91fce744f88212151da1d817e5
Source dataset
uspto-grants-2008_08
Patent number
US07410972B2

Reaction notes

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