Ethyl 2-fluoroacetoacetate → HCID 178432646, compound

HRID 2217992Notes

Reaction equation

HRID 2217992 reaction equation
[F:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14](=[NH:16])[NH2:15])=[N:6]1.[F:21][CH:22]([C:28](=O)[CH3:29])[C:23](OCC)=[O:24]>>[F:21][C:22]1[C:23]([OH:24])=[N:16][C:14]([C:7]2[C:8]3[C:9](=[N:10][CH:11]=[CH:12][CH:13]=3)[N:5]([CH2:4][C:3]3[CH:17]=[CH:18][CH:19]=[CH:20][C:2]=3[F:1])[N:6]=2)=[N:15][C:28]=1[CH3:29]

Participants

3

Reactant 2

HCID 230078Ethyl 2-fluoroacetoacetateHCID 114039861-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide

Product 1

HCID 178432646HCID 178432646, compound

Procedure

The compound is prepared in analogy to example I, step 6. Starting from 650 mg (2.41 mmol) of 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide (example I, step 5) and ethyl 2-fluoro-3-oxobutanoate, 520 mg (60% of theory) of the product are obtained.

Workup

  1. customThe compound is prepared in analogy to example I, step 6
  2. customare obtained

Sources & evidence

ORD record
ord-555baf4f3f0f47199ce61f3482cbe0c7
Source dataset
uspto-grants-2008_08
Patent number
US07410973B2

Reaction notes

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