Propanolamine ethyl ether → HCID 9802227, compound

HRID 2217993Notes

Reaction equation

HRID 2217993 reaction equation
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])[N:10]=2)[N:3]=1.[CH2:26]([O:28][CH2:29][CH2:30][CH2:31][NH2:32])[CH3:27]>CS(C)=O>[CH2:26]([O:28][CH2:29][CH2:30][CH2:31][NH:32][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]=[C:4]([C:9]2[C:17]3[C:12](=[N:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])[N:10]=2)[N:3]=1)[CH3:27]

Participants

4

Reactant 2

HCID 22720Propanolamine ethyl etherHCID 11544891HCID 11544891, compound

Product 1

HCID 9802227HCID 9802227, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent2×

Conditions

Temperature
60 °C

Procedure

35 mg (0.10 mmol) of 3-(4-chloro-6-methyl-2-pyrimidinyl)-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine (example I, step 7) and 52 mg (0.50 mmol) of 3-(ethyloxy)-propylamine are dissolved in 0.40 ml of DMSO and heated at 60° C. for 48 hours. The reaction mixture is diluted with 0.20 ml of DMSO and then purified by preparative

Workup

  1. custompurified by preparative

Sources & evidence

ORD record
ord-1537e4be5f944f08a87dcb176d4d3a50
Source dataset
uspto-grants-2008_08
Patent number
US07410973B2

Reaction notes

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