Phenylboronic Acid → HCID 11773444, compound

HRID 2218007Notes

Reaction equation

HRID 2218007 reaction equation
Br[C:2]1[CH:22]=[CH:21][C:5]2[N:6]([CH3:20])[C:7](=[O:19])[CH2:8][N:9]=[C:10]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[C:4]=2[CH:3]=1.C1(B(O)O)C=CC=CC=1.[CH3:32][O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1B(O)O>>[CH3:32][O:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=1[C:2]1[CH:22]=[CH:21][C:5]2[N:6]([CH3:20])[C:7](=[O:19])[CH2:8][N:9]=[C:10]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[C:4]=2[CH:3]=1

Participants

4

Reactant 3

HCID 66827Phenylboronic AcidHCID 27339582-Methoxyphenylboronic acidHCID 69287689HCID 69287689, compound

Product 1

HCID 11773444HCID 11773444, compoundYield 45%

Procedure

Prepared from 3-(7-bromo-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile Intermediate 14 using the same method described for Example 1 and instead of using benzene boronic acid, we used 2-methoxyphenyl boronic acid. The title compound (85 mg) was obtained as a yellow solid, (yield=45%).

Sources & evidence

ORD record
ord-aa7463b667cb4d12af24372708afbbf4
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

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