Glyoxylic Acid → HCID 10775091, compound

HRID 221802Notes

Reaction equation

HRID 221802 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=O)[CH3:11])=[CH:5][CH:4]=1.[C:13]([OH:17])(=O)[CH:14]=O.O.[NH2:19][NH2:20]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([CH3:11])=[N:20][NH:19][C:13](=[O:17])[CH:14]=2)=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 760Glyoxylic AcidHCID 24654Hydrazine hydrate (1:1)HCID 312311-(p-Methoxyphenyl)-2-propanone

Product 1

HCID 10775091HCID 10775091, compound

Procedure

5-Aryl pyridazinone examples were synthesized as outlined in Schemes 7 and 8. Condensation of 4-methoxyphenyl acetone (R14=Me) with glyoxylic acid (Scheme 7), followed by cyclization with hydrazine hydrate or N-substituted hydrazine derivatives afforded 5-(4-methoxy-phenyl)-6-methyl-2H-pyridazin-3-one, and N—R12 examples (Farmaco, 1987, 43, 539).

Sources & evidence

ORD record
ord-37c9d5ffb1fc4c93bef942e8df775e4b
Source dataset
uspto-grants-2012_06
Patent number
US08207168B2

Reaction notes

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