3,5-Dichlorophenylboronic acid → HCID 11474909, compound

HRID 2218022Notes

Reaction equation

HRID 2218022 reaction equation
Cl[C:2]1[C:3]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:4]=2[N:5]([CH3:10])[C:6](=[O:9])[CH2:7][N:8]=1.C(C1C=C(B(O)O)C=CC=1)=O.[Cl:32][C:33]1[CH:34]=[C:35](B(O)O)[CH:36]=[C:37]([Cl:39])[CH:38]=1>>[Cl:32][C:33]1[CH:34]=[C:35]([C:2]2[C:3]3[CH:14]=[C:13]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH:12]=[CH:11][C:4]=3[N:5]([CH3:10])[C:6](=[O:9])[CH2:7][N:8]=2)[CH:36]=[C:37]([Cl:39])[CH:38]=1

Participants

4

Reactant 3

HCID 27343313,5-Dichlorophenylboronic acidHCID 27343563-Formylphenylboronic acidHCID 69289305HCID 69289305, compound

Product 1

HCID 11474909HCID 11474909, compoundYield 22%

Procedure

Prepared from 5-chloro-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one using the same method described for Example 9 and instead of using 3-formylbenzene boronic acid, we used 3,5-dichlorophenyl boronic acid. The title compound (34 mg) was obtained as a beige solid, (yield=22%).

Sources & evidence

ORD record
ord-2ba483a2321a40de84da37dd03e90134
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

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