3-Formylphenylboronic acid → HCID 11773790, compound

HRID 2218026Notes

Reaction equation

HRID 2218026 reaction equation
Cl[C:2]1[C:3]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:4]=2[N:5]([CH3:10])[C:6](=[O:9])[CH2:7][N:8]=1.C(C1C=C(B(O)O)C=CC=1)=O.[F:32][C:33]([F:44])([F:43])[C:34]1[CH:35]=[C:36](B(O)O)[CH:37]=[CH:38][CH:39]=1>>[CH3:10][N:5]1[C:4]2[CH:11]=[CH:12][C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:14][C:3]=2[C:2]([C:38]2[CH:37]=[CH:36][CH:35]=[C:34]([C:33]([F:44])([F:43])[F:32])[CH:39]=2)=[N:8][CH2:7][C:6]1=[O:9]

Participants

4

Reactant 3

HCID 27343563-Formylphenylboronic acidHCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 69289305HCID 69289305, compound

Product 1

HCID 11773790HCID 11773790, compoundYield 20%

Procedure

Prepared from 5-chloro-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one using the same method described for Example 9 and instead of using 3-formylbenzene boronic acid, we used 3-trifluoromethylphenyl boronic acid. The title compound (30 mg) was obtained as a beige solid, (yield=20%).

Sources & evidence

ORD record
ord-f0e60a2dce714fc494b9e2c01c6e4533
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

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