3-Formylphenylboronic acid → HCID 11257674, compound

HRID 2218028Notes

Reaction equation

HRID 2218028 reaction equation
Cl[C:2]1[C:3]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH:12]=[CH:11][C:4]=2[N:5]([CH3:10])[C:6](=[O:9])[CH2:7][N:8]=1.C(C1C=C(B(O)O)C=CC=1)=O.[CH3:32][O:33][C:34]1[CH:35]=[C:36](B(O)O)[CH:37]=[CH:38][C:39]=1[O:40][CH3:41]>>[CH3:32][O:33][C:34]1[CH:35]=[C:36]([C:2]2[C:3]3[CH:14]=[C:13]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)[CH:12]=[CH:11][C:4]=3[N:5]([CH3:10])[C:6](=[O:9])[CH2:7][N:8]=2)[CH:37]=[CH:38][C:39]=1[O:40][CH3:41]

Participants

4

Reactant 3

HCID 27343563-Formylphenylboronic acidHCID 27347023,4-Dimethoxyphenylboronic acidHCID 69289305HCID 69289305, compound

Product 1

HCID 11257674HCID 11257674, compoundYield 59%

Procedure

Prepared from 5-chloro-1-methyl-7-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one using the same method described for Example 9 and instead of using 3-formylbenzene boronic acid, we used 3,4-dimethoxyphenyl boronic acid. The title compound (88 mg) was obtained as a pale yellow solid, (yield=59%).

Sources & evidence

ORD record
ord-5b5706e690f04916805f646721d52da4
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

Loading…