Phenylboronic Acid → HCID 57478647, compound

HRID 2218034Notes

Reaction equation

HRID 2218034 reaction equation
Br[C:2]1[C:22]([O:23][CH3:24])=[CH:21][C:5]2[N:6]([CH3:20])[C:7](=[O:19])[CH2:8][N:9]=[C:10]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])[C:4]=2[CH:3]=1.C1(B(O)O)C=CC=CC=1.[O:34]([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][C:42]=1B(O)O)[C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1>>[CH3:24][O:23][C:22]1[C:2]([C:36]2[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=2[O:34][C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)=[CH:3][C:4]2[C:10]([C:11]3[CH:12]=[C:13]([CH:16]=[CH:17][CH:18]=3)[C:14]#[N:15])=[N:9][CH2:8][C:7](=[O:19])[N:6]([CH3:20])[C:5]=2[CH:21]=1

Participants

4

Reactant 3

HCID 66827Phenylboronic AcidHCID 2773559(2-Phenoxyphenyl)boronic acidHCID 692877383-(7-bromo-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile

Product 1

HCID 57478647HCID 57478647, compoundYield 72%

Procedure

Prepared from 3-(7-bromo-8-methoxy-1-methyl-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl)-benzonitrile Intermediate 9 using the same method described for Example 1 and instead of using benzene boronic acid, we used 2-phenoxy-phenyl boronic acid The title compound (120 mg) was obtained as a pale green solid, (yield=72%).

Sources & evidence

ORD record
ord-4fe0b7ad02694947990637e515f5db29
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

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