Benzyl Bromide → HCID 11271726, compound

HRID 2218037Notes

Reaction equation

HRID 2218037 reaction equation
[CH3:1][O:2][C:3]1[C:4]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[O:29][CH3:30])=[CH:5][C:6]2[C:12]([C:13]3[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=3)[C:16]#[N:17])=[N:11][CH2:10][C:9](=[O:21])[NH:8][C:7]=2[CH:22]=1.[CH2:31](Br)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[CH2:31]([N:8]1[C:7]2[CH:22]=[C:3]([O:2][CH3:1])[C:4]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=3[O:29][CH3:30])=[CH:5][C:6]=2[C:12]([C:13]2[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=2)[C:16]#[N:17])=[N:11][CH2:10][C:9]1=[O:21])[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 114863203-[8-Methoxy-7-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile

Product 1

HCID 11271726HCID 11271726, compoundYield 90%

Procedure

Prepared from 3-[8-methoxy-7-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-5-yl]-benzonitrile Example 10 using the same method described for Example 35 using benzyl bromine instead of hexyl bromine, we. The title compound (95 mg) was obtained as a yellow solid, (yield=90%).

Sources & evidence

ORD record
ord-f8ed0ee7febe44839bc27322ecb4c4de
Source dataset
uspto-grants-2008_08
Patent number
US07410963B2

Reaction notes

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