Stannous Chloride → HCID 69145393, compound

HRID 2218272Notes

Reaction equation

HRID 2218272 reaction equation
[NH2:1][C:2]1[N:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH:7]=[C:6]([C:26]2[CH:31]=[CH:30][C:29]([N+:32]([O-])=O)=[C:28]([O:35][CH2:36][CH2:37][N:38]3[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]3)[CH:27]=2)[C:3]=1[C:4]#[N:5].Cl[Sn]Cl>CN(C=O)C>[NH2:1][C:2]1[N:9]=[C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)[CH:7]=[C:6]([C:26]2[CH:31]=[CH:30][C:29]([NH2:32])=[C:28]([O:35][CH2:36][CH2:37][N:38]3[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]3)[CH:27]=2)[C:3]=1[C:4]#[N:5]

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 69147767HCID 69147767, compound

Product 1

HCID 69145393HCID 69145393, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A mixture of 2-amino-6-{2-[(4-methoxybenzyl)-oxy]phenyl}-4-{4-nitro-3-[2-(1-piperidinyl)ethoxy]-phenyl}-nicotinonitrile, SnCl2 and DMF was stirred at room temperature overnight. The usual work-up and column chromatography gave 2-amino-4-{4-amino-3-[2-(1-piperidinyl)ethoxy]phenyl}-6-{2-[(4-methoxybenzyl)oxy]-phenyl}nicotinonitrile.

Sources & evidence

ORD record
ord-98ba2fbeaed8474fbd40c0fec2ddce37
Source dataset
uspto-grants-2008_08
Patent number
US07410986B2

Reaction notes

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