Ethylparaben → ethyl 4-(1-t-butoxycarbonyl-4-piperidyloxy)benzoate

HRID 221828Notes

Reaction equation

HRID 221828 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)[CH3:2].[C:13]([O:17][C:18]([N:20]1[CH2:25][CH2:24][CH:23](O)[CH2:22][CH2:21]1)=[O:19])([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18]([N:20]1[CH2:25][CH2:24][CH:23]([O:11][C:8]2[CH:9]=[CH:10][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:12])=[CH:6][CH:7]=2)[CH2:22][CH2:21]1)=[O:19])([CH3:16])([CH3:14])[CH3:15]

Participants

3

Reactant 2

HCID 8434EthylparabenHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 11783050ethyl 4-(1-t-butoxycarbonyl-4-piperidyloxy)benzoate

Procedure

4-(4-Ethoxycarbonylphenoxy)piperidine-1-carboxylic acid tert-butyl ester was prepared from 4-hydroxybenzoic acid ethyl ester and 4-hydroxypiperidine-1-carboxylic acid tert-butyl ester using the procedure described in Example 103 step 1; Mp 76-78° C.; MS m/z 350 (M+H).

Sources & evidence

ORD record
ord-e8019af970644214907ee815d7de45e9
Source dataset
uspto-grants-2012_06
Patent number
US08207168B2

Reaction notes

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