反应详情

温度

60 °C

1-Cyclopropyl-5-methoxy-isoquinoline-7-carboxylic acid methyl ester (4.87 g, 18.9 mmol) was dissolved in THF (50 ml) and MeOH (50 ml), and 5N NaOH aq. (18.9 ml) was added thereto. After stirred at 60° C. for 2 h, the mixture was concentrated in vacuo. The residue was triturated with H2O and 5N HCl aq. (18.9 ml) and the insoluble solid was collected through filtration to obtain the intended compound as a colorless solid.

1. concentrationthe mixture was concentrated in vacuo
2. customThe residue was triturated with H2O and 5N HCl aq. (18.9 ml)
3. filtrationthe insoluble solid was collected through filtration