Thionyl Chloride → HCID 178478508, compound

HRID 2218367Notes

Reaction equation

HRID 2218367 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([C:11]3[CH:20]=[CH:19][C:14]([O:15][CH2:16][CH2:17]O)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1.S(Cl)([Cl:23])=O>>[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([C:11]3[CH:20]=[CH:19][C:14]([O:15][CH2:16][CH2:17][Cl:23])=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 178521371HCID 178521371, compound

Product 1

HCID 178478508HCID 178478508, compound

Procedure

2-[4-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]ethanol (2.0 g, 6 mmol) was dissolved and refluxed in thionyl chloride (30 ml) for 3 h. The excess thionyl chloride was evaporated off and the residue was co-evaporated twice with toluene affording the title product in quantitative yield.

Workup

  1. customThe excess thionyl chloride was evaporated off

Sources & evidence

ORD record
ord-bd7866aa653949939d6bd8c419b26d6d
Source dataset
uspto-grants-2008_08
Patent number
US07410966B2

Reaction notes

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