4-Hydroxypyrrolidine → 1-{3-[4-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-2-hydroxypropyl}pyrrolidin-3-ol

HRID 2218373Notes

Reaction equation

HRID 2218373 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH:19]4[CH2:21][O:20]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1.[NH:22]1[CH2:26][CH2:25][CH:24]([OH:27])[CH2:23]1>>[Br:1][C:2]1[CH:3]=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH:19]([OH:20])[CH2:21][N:22]4[CH2:26][CH2:25][CH:24]([OH:27])[CH2:23]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 178419439HCID 178419439, compound

Product 1

HCID 1785165101-{3-[4-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-yl)phenoxy]-2-hydroxypropyl}pyrrolidin-3-ol

Procedure

The title compound was prepared from 6-bromo-2-[4-(oxiran-2-ylmethoxy)phenyl]-3H-imidazo[4,5-b]pyridine and pyrrolidin-3-ol.

Sources & evidence

ORD record
ord-5fd30363887b4c3f8cf70f52a99f56cf
Source dataset
uspto-grants-2008_08
Patent number
US07410966B2

Reaction notes

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