反应详情

温度

100 °C

2,3-Diamino-4,5-dichloropyridine (Example 206a) (0.50 g, 2.5 mmol) and 4-(2-morpholin-4-ylethoxy)benzoic acid (Example 206c) (0.80 g, 2.5 mmol) were dissolved in POCl3 (10 ml) and heated to 100° C. for 10 h. The excess of POCl3 was evaporated off and the residue was dissolved in EtOAc and aqueous NaHCO3. The aqueous phase was basified with 10M NaOH and extracted three times with EtOAc. The combined organic phases were washed with brine, dried (Na2SO4) and evaporated in vacuo to afford the title product as a slightly yellow powder (0.74 g, 75%).

1. customThe excess of POCl3 was evaporated off
2. dissolutionthe residue was dissolved in EtOAc
3. extractionextracted three times with EtOAc
4. washThe combined organic phases were washed with brine
5. dry with materialdried (Na2SO4)
6. customevaporated in vacuo