Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methylparaben | HCID 7456 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 16111873 | HCID 16111873 | — |
Reaction Steps
Methyl 4-hydroxybenzoate (40 g, 260 mmol) was dissolved in DMF (300 ml), K2CO3 (90 g, 650 mmol) was added and heated to 100° C. 4-(2-Chloroethyl)morpholine hydrochloride (53 g, 280 mmol) was added slowly (35 min) to the slurry. After 2 h at 100° C., the solid was removed by filtration and the solution was evaporated in vacuo. The residue was dissolved in EtOAc and washed with aqueous NaHCO3, brine and dried (Na2SO4) to give the pure product as a white powder in quantitative yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07410966B2 |
|---|
| Source dataset | uspto-grants-2008_08 |
|---|
| ORD ID | ord-500a91bded6740f9b0edb77cc9d3182b |
|---|
| Source note | uspto-grants-2008_08 |
|---|
