反应详情

温度

100 °C

Methyl 4-hydroxybenzoate (40 g, 260 mmol) was dissolved in DMF (300 ml), K2CO3 (90 g, 650 mmol) was added and heated to 100° C. 4-(2-Chloroethyl)morpholine hydrochloride (53 g, 280 mmol) was added slowly (35 min) to the slurry. After 2 h at 100° C., the solid was removed by filtration and the solution was evaporated in vacuo. The residue was dissolved in EtOAc and washed with aqueous NaHCO3, brine and dried (Na2SO4) to give the pure product as a white powder in quantitative yield.

1. customthe solid was removed by filtration
2. customthe solution was evaporated in vacuo
3. dissolutionThe residue was dissolved in EtOAc
4. washwashed with aqueous NaHCO3, brine
5. dry with materialdried (Na2SO4)