3-Amino-1-methanesulfonylpyrrolidine → 6-Chloro-N-[1-(methylsulfonyl)-3-pyrrolidinyl]-2-{4-[2-(4-morpholinyl)ethoxy]phenyl}-1H-imidazo[4,5-b]pyridin-7-amine

HRID 2218385노트

반응식

HRID 2218385 반응식
[Cl:1][C:2]1[C:3](Cl)=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1.[CH3:27][S:28]([N:31]1[CH2:35][CH2:34][CH:33]([NH2:36])[CH2:32]1)(=[O:30])=[O:29]>>[Cl:1][C:2]1[C:3]([NH:36][CH:33]2[CH2:34][CH2:35][N:31]([S:28]([CH3:27])(=[O:30])=[O:29])[CH2:32]2)=[C:4]2[NH:10][C:9]([C:11]3[CH:12]=[CH:13][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)=[CH:15][CH:16]=3)=[N:8][C:5]2=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 533932533-Amino-1-methanesulfonylpyrrolidineHCID 178478272HCID 178478272, 화합물

생성물 1

HCID 117564546-Chloro-N-[1-(methylsulfonyl)-3-pyrrolidinyl]-2-{4-[2-(4-morpholinyl)ethoxy]phenyl}-1H-imidazo[4,5-b]pyridin-7-amine수율 19%

실험 절차

By a procedure similar to that of Example 207 but using 6,7-dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (Example 206) and 1-(methylsulfonyl)pyrrolidin-3-amine, the title compound was obtained in 19% yield.

출처 및 근거

ORD 기록
ord-6f76048c0d7e40f5aaa0314bf3ab65af
출처 데이터셋
uspto-grants-2008_08
특허 번호
US07410966B2

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