2-Morpholinoethylamine → HCID 178478274, compound

HRID 2218400Notes

Reaction equation

HRID 2218400 reaction equation
[Cl:1][C:2]1[C:3](Cl)=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:25][CH2:24][O:23][CH2:22][CH2:21]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1.[N:27]1([CH2:33][CH2:34][NH2:35])[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>>[Cl:1][C:2]1[C:3]([NH:35][CH2:34][CH2:33][N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[C:4]2[N:10]=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH2:18][CH2:19][N:20]4[CH2:21][CH2:22][O:23][CH2:24][CH2:25]4)=[CH:13][CH:12]=3)[NH:8][C:5]2=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 178478272HCID 178478272, compound

Product 1

HCID 178478274HCID 178478274, compoundYield 41.1%

Conditions

Temperature
180 °C

Procedure

6,7-Dichloro-2-[4-(2-morpholin-4-ylethoxy)phenyl]-3H-imidazo[4,5-b]pyridine (Example 206) (0.010 g, 0.025 mmol) was dissolved in 2-morpholin-4-ylethanamine (1 ml, 8 mmol) and heated in a sealed vial at 180° C. for 40 min. The excess amine was removed under reduced pressure, and the solid residue was washed with methanol, giving the title product (0.005 g, 41%).

Workup

  1. customThe excess amine was removed under reduced pressure
  2. washthe solid residue was washed with methanol

Sources & evidence

ORD record
ord-b2cb427e9be24ef4ae880a8252bed67e
Source dataset
uspto-grants-2008_08
Patent number
US07410966B2

Reaction notes

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