反应详情

温度

105 °C

2,3-Diamino-4,5-dichloropyridine (Example 206a) (2.5 g, 14 mmol) and 4-nitrobenzoic acid (2.3 g, 14 mmol) were dissolved in POCl3 (40 ml) and heated to 105° C. for 5 h. The excess of POCl3 was evaporated off and the residue was dissolved in EtOAc and aqueous K2CO3. The aqueous phase was basified with 10M KOH and extracted three times with EtOAc. The combined organic phase was washed with brine, dried (Na2SO4) and evaporated in vacuo to afford the title compound (2.5 g, 58%).

1. customThe excess of POCl3 was evaporated off
2. dissolutionthe residue was dissolved in EtOAc
3. extractionextracted three times with EtOAc
4. washThe combined organic phase was washed with brine
5. dry with materialdried (Na2SO4)
6. customevaporated in vacuo