反应详情

A mixture of 1-(3-aminopropyl)-2-pyrrolidinone (560 μL, 4 mmol) and benzoyl isothiocyanate (536 μL, 4 mmol) was dissolved in chloroform (3 mL), stirred at room temperature for 30 min, then concentrated in vacuo. The resulting residue was dissolved in concentrated HCl (3 mL), heated at 95° C. for 2 h, then concentrated in vacuo. The resulting residue was dissolved in water and washed with dichloromethane (2×30 mL), then basified with 2 M NaOH and extracted with dichloromethane (2×30 mL). The combined extracts were dried over MgSO4 and concentrated to provide 1-(3-(2-oxopyrrolidin-1-yl)propyl)thiourea (638 mg) as a pale yellow oil.

1. concentrationconcentrated in vacuo
2. dissolutionThe resulting residue was dissolved in concentrated HCl (3 mL)
3. temperatureheated at 95° C. for 2 h
4. concentrationconcentrated in vacuo
5. dissolutionThe resulting residue was dissolved in water
6. washwashed with dichloromethane (2×30 mL)
7. extractionextracted with dichloromethane (2×30 mL)
8. dry with materialThe combined extracts were dried over MgSO4
9. concentrationconcentrated