Malononitrile → HCID 178423906, compound

HRID 2218532Notes

Reaction equation

HRID 2218532 reaction equation
O=[C:2]1[C:5](=[O:6])[C:4]([O-:7])=[C:3]1[CH:8]=[C:9]1[C:17]([CH3:19])([CH3:18])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26].[CH2:28]([NH+:30]([CH2:33][CH3:34])[CH2:31][CH3:32])[CH3:29].[C:35](#[N:39])[CH2:36][C:37]#[N:38]>C(O)C>[C:37]([C:36]([C:35]#[N:39])=[C:2]1[C:5](=[O:6])[C:4]([O-:7])=[C:3]1[CH:8]=[C:9]1[C:17]([CH3:19])([CH3:18])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]1[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([OH:27])=[O:26])#[N:38].[CH2:28]([NH+:30]([CH2:33][CH3:34])[CH2:31][CH3:32])[CH3:29]

Participants

4

Reactant 2

HCID 8010MalononitrileHCID 86600556HCID 86600556, compound

Product 1

HCID 178423906HCID 178423906, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 1.2 g (2.82 mmol) of 11, 190 mg (2.87 mmol) of malononitrile and 0.4 ml (2.85 mmol) of TEA in 15 ml of ethanol was stirred at room temperature for 2.5 h. Then solvent was removed by a rotary evaporator. Product 12 was used in next synthesis without further purification.

Workup

  1. customThen solvent was removed by a rotary evaporator
  2. customProduct 12 was used in next synthesis without further purification

Sources & evidence

ORD record
ord-0ce75da7a76c4ad3ade620c5e25afcc5
Source dataset
uspto-grants-2008_08
Patent number
US07411068B2

Reaction notes

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