2-Chlorobenzoyl chloride → HCID 9836557, compound

HRID 2218538Notes

Reaction equation

HRID 2218538 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[NH2:11][C:12]1[C:13](=[O:23])[O:14][C:15]2[CH:21]=[C:20]([OH:22])[CH:19]=[CH:18][C:16]=2[CH:17]=1>Cl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH:11][C:12]1[C:13](=[O:23])[O:14][C:15]2[CH:21]=[C:20]([OH:22])[CH:19]=[CH:18][C:16]=2[CH:17]=1)=[O:5]

Participants

4

Reactant 2

HCID 691102-Chlorobenzoyl chlorideHCID 573458543-Amino-7-hydroxy-2H-1-benzopyran-2-one

Product 1

HCID 9836557HCID 9836557, compoundYield 54.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-Chlorobenzoyl chloride (23.0 mg, 0.291 mmol) was added to a mixture of 3-amino-7-hydroxy-2H-1-benzopyran-2-one (50.0 mg, 0.282 mmol), and the mixture was stirred at room temparature for 1 hour. 1N hydrochloric acid (10 ml) was added, and the mixture was stirred. The precipitated crystal was filtered and washed successively with water and diisopropyl ether to give the title compound as a light brown crystal (48.8 mg, 54.8%).

Workup

  1. stirringthe mixture was stirred
  2. filtrationThe precipitated crystal was filtered
  3. washwashed successively with water and diisopropyl ether

Sources & evidence

ORD record
ord-92ea5e4589884df097c827e6ff95bb8c
Source dataset
uspto-grants-2008_08
Patent number
US07411076B2

Reaction notes

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