ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochloride → ethyl(1r,2s)-2-aminocyclohexanecarboxylate

HRID 2218565Notes

Reaction equation

HRID 2218565 reaction equation
Cl.[CH2:2]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH2:13])=[O:6])[CH3:3]>[OH-].[Na+]>[CH2:2]([O:4][C:5]([C@@H:7]1[CH2:12][CH2:11][CH2:10][CH2:9][C@@H:8]1[NH2:13])=[O:6])[CH3:3]

Participants

3

Reactant 1

HCID 2724641ethyl (1R,2S)-2-aminocyclohexane-1-carboxylate hydrochloride

Product 1

HCID 818060ethyl(1r,2s)-2-aminocyclohexanecarboxylateYield 92.2%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

Ethyl-cis-2-amino-1-cyclohexanecarboxylate hydrochloride (750 mg) was suspended in 1 N NaOH (pH =12). The aqueous layer was extracted with CH2Cl2, washed with brine, dried over Na2SO4 and evaporated to give the crude ethyl-cis-2-amino- 1-cyclohexanecarboxylate (570 mg).

Workup

  1. extractionThe aqueous layer was extracted with CH2Cl2
  2. washwashed with brine
  3. dry with materialdried over Na2SO4
  4. customevaporated

Sources & evidence

ORD record
ord-0a8bcbe64fde474dac87d58794b79a2c
Source dataset
uspto-grants-2008_08
Patent number
US07411093B2

Reaction notes

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