反应详情

Under a nitrogen atmosphere, 20 g of 4,4-bis(trifluoromethyl)-4-hydroxy-1-butene (96.1 mmol), 8.05 g of thioacetic acid (105.7 mmol), 60 g of 1,4-dioxane and 0.79 g of 2,2′-azobisisobutyronitrile (hereinafter abbreviated as AIBN) (4.8 mmol) were put into a flask equipped with a stirring bar, a thermometer and a condenser, and heated with stirring. During the reaction, thioacetic acid and AIBN were appropriately added and after confirming that a substrate was completely consumed, the reaction solution was distilled as it was under reduced pressure to yield an intermediate product, 22 g of 4-acetylthio-1,1-bis(trifluoromethyl)-1-butanol (76.9 mmol).

1. customwere put into a flask
2. customequipped with a stirring bar
3. temperaturea thermometer and a condenser, and heated
4. additionwere appropriately added
5. customwas completely consumed
6. distillationthe reaction solution was distilled as it