1-Propanesulfonyl chloride → HCID 59770420, compound

HRID 2218646Notes

Reaction equation

HRID 2218646 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:24]([S:27](Cl)(=[O:29])=[O:28])[CH2:25][CH3:26]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH:23][S:27]([CH2:24][CH2:25][CH3:26])(=[O:29])=[O:28])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 662791-Propanesulfonyl chlorideHCID 59769897HCID 59769897, compound

Product 1

HCID 59770420HCID 59770420, compoundYield 50.2%

Procedure

Following procedures essentially as described in Example 90, 3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylamine (50 mg, 0.168 mmol) and 1-propanesulfonyl chloride (144 mg, 1.01 mmol) affords 34 mg (50%) of the title compound as a white foam. MS (ES) 426 M+Na), 402 (M−H); HPLC shows 99% purity.

Sources & evidence

ORD record
ord-3414fdb9621a49bcb4c195b786e6b63e
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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