1-Butanesulfonyl chloride → HCID 59770388, compound

HRID 2218647Notes

Reaction equation

HRID 2218647 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH2:23])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:24]([S:28](Cl)(=[O:30])=[O:29])[CH2:25][CH2:26][CH3:27]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:18]=[C:19]([NH:23][S:28]([CH2:24][CH2:25][CH2:26][CH3:27])(=[O:30])=[O:29])[CH:20]=[CH:21][CH:22]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 754301-Butanesulfonyl chlorideHCID 59769897HCID 59769897, compound

Product 1

HCID 59770388HCID 59770388, compoundYield 58.4%

Procedure

Following procedures essentially as described in Example 90, 3-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylamine (50 mg, 0.168 mmol) and 1-butanesulfonyl chloride (158 mg, 1.01 mmol) affords 41 mg (58%) of the title compound as a colorless oil. MS (ES) 440 (M+Na); HPLC shows 99% purity.

Sources & evidence

ORD record
ord-11c1f52eba174d849177e58a1fe94da5
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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