1-Propanesulfonyl chloride → HCID 59770266, compound

HRID 2218649Notes

Reaction equation

HRID 2218649 reaction equation
[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1.[CH2:24]([S:27](Cl)(=[O:29])=[O:28])[CH2:25][CH3:26]>>[CH:1]1[C:11]2[CH2:10][CH2:9][C:8]3[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=3[C:6](=[CH:16][C:17]3[CH:22]=[CH:21][C:20]([NH:23][S:27]([CH2:24][CH2:25][CH3:26])(=[O:29])=[O:28])=[CH:19][CH:18]=3)[C:5]=2[CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 662791-Propanesulfonyl chlorideHCID 59769900HCID 59769900, compound

Product 1

HCID 59770266HCID 59770266, compoundYield 51%

Procedure

Following procedures essentially as described in Example 90, 4-(10,11-dihydro-dibenzo[a,d]cyclohepten-5-ylidenemethyl)-phenylamine (100 mg, 0.336 mmol) and 1-propanesulfonyl chloride (144 mg, 1.01 mmol) affords 69 mg (51%) of the title compound as a colorless oil. MS (ES) 426 (M+Na), 402 (M−H); HPLC shows 99% purity.

Sources & evidence

ORD record
ord-c84bb09825034934be573a23c7d76b68
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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