反应详情

Add 5-(3,5-bis-trifluoromethyl-benzylidene)-10,11-dihydro-5H-dibenzo [a,d]cycloheptene (0.28 g, 0.67 mmol) to a mixture of 10% Pd/C (0.08 g) suspended in absolute ethanol (4.0 mL) and ethyl acetate (4.0 mL) and hydrogenate under a balloon of hydrogen at room temperature and pressure. Stir for 17 h, remove the catalyst via filtration through a pad of Celite. Evaporate the filtrate and pass through a plug of silica gel equilibrated with hexanes. Concentrate the filtrate to give the title product. MS (m/e): 420 (M+); Analysis for C24H18F6: Calcd: C, 68.56 H, 4.31. Found: C, 68.55 H. 4.01.

1. customat room temperature
2. customremove the catalyst
3. filtrationvia filtration through a pad of Celite
4. customEvaporate the filtrate and pass through a plug of silica gel
5. concentrationConcentrate the filtrate