10,11-dihydro-5H-dibenzo(a,d)cycloheptene → HCID 59769864, compound

HRID 2218676Notes

Reaction equation

HRID 2218676 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH:4]=O.[CH2:12]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13]1>>[F:1][C:2]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][C:3]=1[CH:4]=[C:20]1[C:19]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH2:13][CH2:12][C:26]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]1=2

Participants

3

Reactant 2

HCID 7002910,11-dihydro-5H-dibenzo(a,d)cyclohepteneHCID 27348722-Fluoro-5-methoxybenzaldehyde

Product 1

HCID 59769864HCID 59769864, compoundYield 6.4%

Procedure

Following procedures essentially as described in Example 28 and using 2-fluoro-5-methoxybenzaldehyde (1.59 g, 10.3 mmol) and dibenzosuberane (1.94 g, 10 mmol), provides 210 mg of title compound as white crystals. mp 110.7° C. (hexane). HPLC shows 99% purity.

Sources & evidence

ORD record
ord-4496c38afd0148d7a2943a050cb1fde9
Source dataset
uspto-grants-2008_08
Patent number
US07411072B2

Reaction notes

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